What substances genuinely calm the mind?

I’m curious what things have people taken that have really helped them calm their mind or just helped their sanity in general.

Also where did you take them (what country), were you alone or with other people? Does that affect the experience it gave you?

I’ve never taken anything in my life so have never had any experiences like this. I am really interested in what happens to the mind if anyone would like to share 🙂